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Hypersensitivity reactions: Gell and Goombs nomenclature

ACID
· From I to IV:
Anaphylactic type: type I
Cytotoxic type: type II
Immune complex disease: type III
Delayed hypersensitivity (cell mediated): type IV
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---Anonymous Contributor

MHC I vs. II: T cell interaction

The "=8" equation:
2x4=8, and 1x8=8.
MHC II goes with CD4.
MHC I goes with CD8.
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---Anonymous Contributor

Immunoglobulin (Ig) types: the important ones worth remembering, in order of appearance

MAGDElaine (a girl's name):
IgM
IgA
IgG
IgD
IgE
· Magdelaine tells you the order they usually appear: M first, then A or G.
· Alternatively: IgM is IMmediate.
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---Magdelaine Deeby and Anonymous Contributor University College Dublin and University of Aberdeen

Acute inflammation features

SLIPR:
Swelling
Loss of function
Increased heat
Pain
Redness
· "What a cute pair of slippers" can be used to tie acute inflammation to SLIPR.
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---Robert O'Connor University College Dublin

Lupus signs and symptoms

SOAP BRAIN:
Serositis [pleuritis, pericarditis]
Oral ulcers
Arthritis
Photosensitivity
Blood [all are low - anemia, leukopenia, thrombocytopenia]
Renal [protein]
ANA
Immunologic [DS DNA, etc.]
Neurologic [psych, seizures]
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---Ken Evans Saskatchewan Health, Acute and Emergency Services

Goodpasture's Syndrome components

GoodPasture is Glomerulonephritis and Pnuemonitits.
· From autoantibodies attacking Glomerular and Pulmonary basement membranes.
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---Robert O'Connor University College Dublin

Complement: function of C3a versus C3b

C3a: Activates Acute [inflammation].
C3b: Bonds Bacteria [to macrophages--easier digestion].
· If wish to know more than just C3:
C3a, C4a, C5a activate acute.
C3b, C4b bind bacteria.
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---Robert O'Connor and Marcus Fidel University College Dublin and UNM

MHC I vs. MHC II properties

"Immunity helps to exterminate fun for bacteria"
· See attached chart.

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---Robert O'Connor University College Dublin

HLA-DR genetic predisposition immune disease examples

HLA-DR:
Hashimoto's disease
Leukemia/ Lupus
Autoimmune adrenalitis/ Anemia (pernicious)
Diabetes insipidous
Rheumatoid arthritis
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---Robert O'Connor and Dr. Chetan Wiskar

Complement cascade initiating items: alternative vs. classic

Classic: Combined Complexes.
Alternative: Activators Alone, or IgA.
· Complexes are made of Ab and Ag combined together.
· Examples of activators: endotoxin, microbial surface.
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---Robert O'Connor University College Dublin